Importance of Shank3 Protein in Regulating Metabotropic Glutamate Receptor 5 (mGluR5) Expression and Signaling at Synapses

Shank3/PROSAP2 gene mutations are associated with cognitive impairment ranging from mental retardation to autism. Shank3 is a large scaffold postsynaptic density protein implicated in dendritic spines and synapse formation; however, its specific functions have not been clearly demonstrated. We have...

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Hauptverfasser: Verpelli, Chiara, Dvoretskova, Elena, Vicidomini, Cinzia, Rossi, Francesca, Chiappalone, Michela, Schoen, Michael, Di Stefano, Bruno, Mantegazza, Renato, Broccoli, Vania, Böckers, Tobias M., Dityatev, Alexander, Sala, Carlo
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Neurobiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186429/
https://ncbi.nlm.nih.gov/pubmed/21795692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.258384
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