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Aberrant expression of p16(INK4a) in human cancers – a new biomarker?
The ARF and INK4a genes are located in the same CDKN2a locus, both showing its tumor suppressive activity. ARF has been shown to detect potentially harmful oncogenic signals, making incipient cancer cells undergo senescence or apoptosis. INK4a, on the other hand, responds to signals from aging in a...
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| Published in: | Cancer Rep Rev |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6018005/ https://ncbi.nlm.nih.gov/pubmed/29951643 |
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