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High frequency of aberrant p16(INK4A) expression in human breast cancer.

The product of the CDKN2/MTS1 gene, p16(INK4A) (16), inhibits phosphorylation of the retinoblastoma protein, pRB, and thus acts as a negative cell cycle regulator. It is inactivated in a wide range of human malignancies, including breast cancer. Using an immunohistochemical approach, we studied the...

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Autors principals: Geradts, J., Wilson, P. A.
Format: Artigo
Idioma:Inglês
Publicat: 1996
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1865226/
https://ncbi.nlm.nih.gov/pubmed/8686738
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