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Aberrant expression of cyclin D1 in cancer
Cyclin D1 binds and activates cyclin-dependent kinases 4/6 (Cdk4/6) to phosphorylate the retinoblastoma (RB) family proteins, relieving E2F/DPs from the negative restraint of RB proteins and histone deacetylases. The cyclin D-Cdk4/6 complexes activate cyclin E/Cdk2 through titration of the Cdk inhib...
Shranjeno v:
| izdano v: | Sign Transduct Insights |
|---|---|
| Main Authors: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5226649/ https://ncbi.nlm.nih.gov/pubmed/28090171 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4137/STI.S30306 |
| Oznake: |
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