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Pharmacokinetic–Pharmacodynamic Model for the Testosterone-Suppressive Effect of Leuprolide in Normal and Prostate Cancer Rats

This study developed the pharmacokinetic (PK)–pharmacodynamic (PD) model of the testosterone-suppressive effect of leuprolide for evaluation of the sustained release (SR) depot and leuprolide solution in rats with or without prostate cancer. Six groups of rats were divided by the routes of administr...

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Bibliografske podrobnosti
izdano v:Molecules
Main Authors: Lee, Dong-Seok, Kim, Sook-Jin, Choi, Go-Wun, Lee, Yong-Bok, Cho, Hea-Young
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6017563/
https://ncbi.nlm.nih.gov/pubmed/29662027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23040909
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