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Interpretation of Non-Clinical Data for Prediction of Human Pharmacokinetic Parameters: In Vitro-In Vivo Extrapolation and Allometric Scaling

Extrapolation of pharmacokinetic (PK) parameters from in vitro or in vivo animal to human is one of the main tasks in the drug development process. Translational approaches provide evidence for go or no-go decision-making during drug discovery and the development process, and the prediction of human...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Pharmaceutics
Päätekijät: Choi, Go-Wun, Lee, Yong-Bok, Cho, Hea-Young
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: MDPI 2019
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6523982/
https://ncbi.nlm.nih.gov/pubmed/30959827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics11040168
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