Potent GH20 N-Acetyl-β-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols

From 1,2;3,4-di-O-isopropylidene-d-galactopyranose, a preliminary series of highly functionalized amino(hydroxymethyl)cyclopentanes was easily available. These amine-containing basic carbasugars featuring the d-galacto configuration are potent inhibitors of the GH20 β-d-hexosaminidases probed and ma...

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Publicado no:Molecules
Main Authors: Weber, Patrick, Nasseri, Seyed A., Pabst, Bettina M., Torvisco, Ana, Müller, Philipp, Paschke, Eduard, Tschernutter, Marion, Windischhofer, Werner, Withers, Stephen G., Wrodnigg, Tanja M., Stütz, Arnold E.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6017319/
https://ncbi.nlm.nih.gov/pubmed/29558439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23030708
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