Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and C-5a-Substituted Derivatives of 4-epi-Isofagomine

Glycosidase inhibitors have shown great potential as pharmacological chaperones for lysosomal storage diseases. In light of this, a series of new cyclopentanoid β-galactosidase inhibitors were prepared and their inhibitory and pharmacological chaperoning activities determined and compared with those...

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Publicado no:Molecules
Main Authors: Weber, Patrick, Thonhofer, Martin, Averill, Summer, Davies, Gideon J., Santana, Andres Gonzalez, Müller, Philipp, Nasseri, Seyed A., Offen, Wendy A., Pabst, Bettina M., Paschke, Eduard, Schalli, Michael, Torvisco, Ana, Tschernutter, Marion, Tysoe, Christina, Windischhofer, Werner, Withers, Stephen G., Wolfsgruber, Andreas, Wrodnigg, Tanja M., Stütz, Arnold E.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7504770/
https://ncbi.nlm.nih.gov/pubmed/32899288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25174025
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