Identification of ethyl pyruvate as a NLRP3 inflammasome inhibitor that preserves mitochondrial integrity

BACKGROUND: The NLRP3 inflammasome, a cytosolic complex that mediates the maturation of IL-1β and IL-18 as well as the release of high mobility group box 1 (HMGB1), contributes to the lethality of endotoxic shock. Ethyl pyruvate (EP) was previously shown to inhibit HMGB1 release and promote survival...

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Udgivet i:Mol Med
Main Authors: Li, Sujun, Liang, Fang, Kwan, Kevin, Tang, Yiting, Wang, Xiangyu, Tang, Youzhou, Li, Jianhua, Yang, Huan, Chavan, Sangeeta S., Wang, Haichao, Andersson, Ulf, Lu, Ben, Tracey, Kevin J.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016887/
https://ncbi.nlm.nih.gov/pubmed/30134814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s10020-018-0006-9
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