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The Cytoplasmic Domain of the Integrin α9 Subunit Requires the Adaptor Protein Paxillin to Inhibit Cell Spreading but Promotes Cell Migration in a Paxillin-independent Manner

The integrin α9 subunit forms a single heterodimer, α9β1. The α9 subunit is most closely related to the α4 subunit, and like α4 integrins, α9β1 plays an important role in leukocyte migration. The α4 cytoplasmic domain preferentially enhances cell migration and inhibits cell spreading, effects that d...

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Udgivet i:Mol Biol Cell
Principais autores: Young, Bradford A., Taooka, Yasuyuki, Liu, Shouchun, Askins, Karen J., Yokosaki, Yasuyuki, Thomas, Sheila M., Sheppard, Dean
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Cell Biology 2001
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC60168/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11598204/
https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.12.10.3214
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