Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia.

Integrins are membrane receptors which mediate cell-cell or cell-matrix adhesion. Integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) acts as a fibrinogen receptor of platelets and mediates platelet aggregation. Platelet activation is required for alpha IIb beta 3 to shift from noncompetent to compete...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Chen, Y P, Djaffar, I, Pidard, D, Steiner, B, Cieutat, A M, Caen, J P, Rosa, J P
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1992
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50299/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1438206/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.21.10169
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