Superoxide constricts rat pulmonary arteries via Rho-kinase-mediated Ca(2+) sensitization

Reactive oxygen species play a key role in vascular disease, pulmonary hypertension, and hypoxic pulmonary vasoconstriction. We investigated contractile responses, intracellular Ca(2+) ([Ca(2+)](i)), Rho-kinase translocation, and phosphorylation of the regulatory subunit of myosin phosphatase (MYPT-...

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Detalhes bibliográficos
Publicado no:Free Radic Biol Med
Main Authors: Knock, Greg A., Snetkov, Vladimir A., Shaifta, Yasin, Connolly, Michelle, Drndarski, Svetlana, Noah, Anthony, Pourmahram, Ghazaleh E., Becker, Silke, Aaronson, Philip I., Ward, Jeremy P.T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016743/
https://ncbi.nlm.nih.gov/pubmed/19103285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2008.11.015
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