Sphingosylphosphorylcholine potentiates vasoreactivity and voltage-gated Ca(2+) entry via NOX1 and reactive oxygen species

AIMS: Sphingosylphosphorylcholine (SPC) elicits vasoconstriction at micromolar concentrations. At lower concentrations (≤1 µmol/L), however, it does not constrict intrapulmonary arteries (IPAs), but strongly potentiates vasoreactivity. Our aim was to determine whether this also occurs in a systemic...

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Publicat a:Cardiovasc Res
Autors principals: Shaifta, Yasin, Snetkov, Vladimir A., Prieto-Lloret, Jesus, Knock, Greg A., Smirnov, Sergey V., Aaronson, Philip I., Ward, Jeremy P.T.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362402/
https://ncbi.nlm.nih.gov/pubmed/25661082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvv029
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