LOW CONCENTRATIONS OF SPHINGOSYLPHOSPHORYLCHOLINE ENHANCE PULMONARY ARTERY VASOREACTIVITY: ROLE OF PKCδ AND Ca(2+) ENTRY

Sphingosylphosphorylcholine (SPC) is a powerful vasoconstrictor, but in vitro its EC(50) is ∼100-fold more than plasma concentrations. We examined whether sub-contractile concentrations of SPC (≤1 μmol/l) modulated vasoreactivity of rat intrapulmonary arteries (IPA), using myography and measurement...

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Autori principali: Snetkov, Vladimir A., Thomas, Gavin D., Teague, Bonnie, Leach, Richard M., Shaifta, Yasin, Knock, Greg A., Aaronson, Philip I., Ward, Jeremy P.T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2231840/
https://ncbi.nlm.nih.gov/pubmed/18158336
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