ROS-dependent activation of RhoA/Rho-kinase in pulmonary artery: Role of Src-family kinases and ARHGEF1

The role of reactive oxygen species (ROS) in smooth muscle contraction is poorly understood. We hypothesised that G-protein coupled receptor (GPCR) activation and hypoxia induce Rho-kinase activity and contraction in rat intra-pulmonary artery (IPA) via stimulation of ROS production and subsequent S...

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Detalhes bibliográficos
Publicado no:Free Radic Biol Med
Principais autores: MacKay, Charles E., Shaifta, Yasin, Snetkov, Vladimir V., Francois, Asvi A., Ward, Jeremy P.T., Knock, Greg A.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5542024/
https://ncbi.nlm.nih.gov/pubmed/28673614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2017.06.022
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