CFTR/ENaC-dependent regulation of membrane potential during human sperm capacitation is initiated by bicarbonate uptake through NBC

To fertilize an egg, sperm must reside in the female reproductive tract to undergo several maturational changes that are collectively referred to as capacitation. From a molecular point of view, the HCO(3)(−)-dependent activation of the atypical soluble adenylyl cyclase (ADCY10) is one of the first...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Puga Molina, Lis C., Pinto, Nicolás A., Torres, Nicolás I., González-Cota, Ana L., Luque, Guillermina M., Balestrini, Paula A., Romarowski, Ana, Krapf, Dario, Santi, Celia M., Treviño, Claudia L., Darszon, Alberto, Buffone, Mariano G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016479/
https://ncbi.nlm.nih.gov/pubmed/29743243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003166
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