CFTR/ENaC-dependent regulation of membrane potential during human sperm capacitation is initiated by bicarbonate uptake through NBC

To fertilize an egg, sperm must reside in the female reproductive tract to undergo several maturational changes that are collectively referred to as capacitation. From a molecular point of view, the HCO(3)(−)-dependent activation of the atypical soluble adenylyl cyclase (ADCY10) is one of the first...

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Vydáno v:J Biol Chem
Hlavní autoři: Puga Molina, Lis C., Pinto, Nicolás A., Torres, Nicolás I., González-Cota, Ana L., Luque, Guillermina M., Balestrini, Paula A., Romarowski, Ana, Krapf, Dario, Santi, Celia M., Treviño, Claudia L., Darszon, Alberto, Buffone, Mariano G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016479/
https://ncbi.nlm.nih.gov/pubmed/29743243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003166
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