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CFTR/ENaC-dependent regulation of membrane potential during human sperm capacitation is initiated by bicarbonate uptake through NBC

To fertilize an egg, sperm must reside in the female reproductive tract to undergo several maturational changes that are collectively referred to as capacitation. From a molecular point of view, the HCO(3)(−)-dependent activation of the atypical soluble adenylyl cyclase (ADCY10) is one of the first...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Puga Molina, Lis C., Pinto, Nicolás A., Torres, Nicolás I., González-Cota, Ana L., Luque, Guillermina M., Balestrini, Paula A., Romarowski, Ana, Krapf, Dario, Santi, Celia M., Treviño, Claudia L., Darszon, Alberto, Buffone, Mariano G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016479/
https://ncbi.nlm.nih.gov/pubmed/29743243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003166
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