Differential activities and mechanisms of the four R-spondins in potentiating Wnt/β-catenin signaling

The four R-spondins (RSPO1–4) strongly potentiate Wnt signaling and play critical roles in normal development, adult stem cell survival, and cancer development and aggressiveness. All four RSPOs have been suggested to potentiate Wnt signaling by binding to three related receptors, i.e. leucine-rich...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Park, Soohyun, Cui, Jie, Yu, Wangsheng, Wu, Ling, Carmon, Kendra S., Liu, Qingyun J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2018
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016459/
https://ncbi.nlm.nih.gov/pubmed/29752411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002743
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