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Unlike LGR4, LGR5 potentiates Wnt–β-catenin signaling without sequestering E3 ligases
LGR4 and LGR5 encode two homologous receptors with critical yet distinct roles in organ development and adult stem cell survival. Both receptors are co-expressed in intestinal crypt stem cells, bind to R-spondins (RSPOs) with high affinity, and potentiate Wnt/β-catenin signaling, presumably by the s...
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| Опубликовано в: : | Sci Signal |
|---|---|
| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7905944/ https://ncbi.nlm.nih.gov/pubmed/33262293 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaz4051 |
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