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Differential activities and mechanisms of the four R-spondins in potentiating Wnt/β-catenin signaling
The four R-spondins (RSPO1–4) strongly potentiate Wnt signaling and play critical roles in normal development, adult stem cell survival, and cancer development and aggressiveness. All four RSPOs have been suggested to potentiate Wnt signaling by binding to three related receptors, i.e. leucine-rich...
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| Publicado en: | J Biol Chem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6016459/ https://ncbi.nlm.nih.gov/pubmed/29752411 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002743 |
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