Differential activities and mechanisms of the four R-spondins in potentiating Wnt/β-catenin signaling

The four R-spondins (RSPO1–4) strongly potentiate Wnt signaling and play critical roles in normal development, adult stem cell survival, and cancer development and aggressiveness. All four RSPOs have been suggested to potentiate Wnt signaling by binding to three related receptors, i.e. leucine-rich...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Park, Soohyun, Cui, Jie, Yu, Wangsheng, Wu, Ling, Carmon, Kendra S., Liu, Qingyun J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2018
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016459/
https://ncbi.nlm.nih.gov/pubmed/29752411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002743
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