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Regioselective Base-Mediated Cyclizations of Mono-N-acylpropargylguanidines

A regioselective base-mediated cyclization of mono-N-acylpropargylguanidines is reported. A related Ag(I)-catalyzed hydroamination strategy was recently employed to yield N(3)-Cbz-protected ene-guanidines, which found utility in the synthesis of naamidine A. Herein, we report the base-catalyzed hydr...

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Bibliographic Details
Published in:J Org Chem
Main Authors: Salvant, Justin M., Edwards, Anne V., Kurek, Daniel Z., Looper, Ryan E.
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016371/
https://ncbi.nlm.nih.gov/pubmed/28558466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.7b00639
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