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Chlorotrimethylsilane activation of acylcyanamides for the synthesis of mono-N-acylguanidines
[Image: see text] A simple and efficient one-pot method for the synthesis of mono-protected guanidines is presented. Treatment of an acylcyanamide with chlorotrimethylsilane generates a reactive N-silylcarbodiimide capable of guanylating a variety of amines. Typically the reaction is complete in 15...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3189699/ https://ncbi.nlm.nih.gov/pubmed/21732649 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo201264j |
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