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Mechanism-based inhibition of an aldolase at high concentrations of its natural substrate acetaldehyde: structural insights and protective strategies

2-Deoxy-d-ribose-5-phosphate aldolase (DERA) is used in organic synthesis for the enantioselective reaction between acetaldehyde and a broad range of other aldehydes as acceptor molecules. Nevertheless, its application is hampered by a poor tolerance towards high concentrations of acetaldehyde, its...

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Bibliografiske detaljer
Udgivet i:Chem Sci
Main Authors: Dick, Markus, Hartmann, Rudolf, Weiergräber, Oliver H., Bisterfeld, Carolin, Classen, Thomas, Schwarten, Melanie, Neudecker, Philipp, Willbold, Dieter, Pietruszka, Jörg
Format: Artigo
Sprog:Inglês
Udgivet: Royal Society of Chemistry 2016
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016325/
https://ncbi.nlm.nih.gov/pubmed/30155096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc04574f
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