Conformational Sampling of the Intrinsically Disordered C-Terminal Tail of DERA Is Important for Enzyme Catalysis

[Image: see text] 2-Deoxyribose-5-phosphate aldolase (DERA) catalyzes the reversible conversion of acetaldehyde and glyceraldehyde-3-phosphate into deoxyribose-5-phosphate. DERA is used as a biocatalyst for the synthesis of drugs such as statins and is a promising pharmaceutical target due to its in...

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Publicado en:ACS Catal
Autores principales: Schulte, Marianne, Petrović, Dušan, Neudecker, Philipp, Hartmann, Rudolf, Pietruszka, Jörg, Willbold, Sabine, Willbold, Dieter, Panwalkar, Vineet
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2018
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6080863/
https://ncbi.nlm.nih.gov/pubmed/30101036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.7b04408
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