Glycosphingolipid levels and glucocerebrosidase activity are altered in normal aging of the mouse brain

Aging is the predominant risk factor for both genetic and sporadic Parkinson’s disease (PD). The majority of PD cases are nonfamilial, and the connection between aging and PD-associated genes is not well understood. Haploinsufficiency of the GBA gene, leading to a reduction in glucocerebrosidase (GC...

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Udgivet i:Neurobiol Aging
Main Authors: Hallett, Penelope J., Huebecker, Mylene, Brekk, Oeystein R., Moloney, Elizabeth B., Rocha, Emily M., Priestman, David A., Platt, Frances M., Isacson, Ole
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6015735/
https://ncbi.nlm.nih.gov/pubmed/29735433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2018.02.028
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