Glycosphingolipid levels and glucocerebrosidase activity are altered in normal aging of the mouse brain

Aging is the predominant risk factor for both genetic and sporadic Parkinson’s disease (PD). The majority of PD cases are nonfamilial, and the connection between aging and PD-associated genes is not well understood. Haploinsufficiency of the GBA gene, leading to a reduction in glucocerebrosidase (GC...

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Pubblicato in:Neurobiol Aging
Autori principali: Hallett, Penelope J., Huebecker, Mylene, Brekk, Oeystein R., Moloney, Elizabeth B., Rocha, Emily M., Priestman, David A., Platt, Frances M., Isacson, Ole
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6015735/
https://ncbi.nlm.nih.gov/pubmed/29735433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2018.02.028
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