Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson’s disease

BACKGROUND: Haploinsufficiency in the Gaucher disease GBA gene, which encodes the lysosomal glucocerebrosidase GBA, and ageing represent major risk factors for developing Parkinson’s disease (PD). Recently, more than fifty other lysosomal storage disorder gene variants have been identified in PD, im...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Huebecker, Mylene, Moloney, Elizabeth B., van der Spoel, Aarnoud C., Priestman, David A., Isacson, Ole, Hallett, Penelope J., Platt, Frances M.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6842240/
https://ncbi.nlm.nih.gov/pubmed/31703585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-019-0339-z
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados