Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson’s disease

BACKGROUND: Haploinsufficiency in the Gaucher disease GBA gene, which encodes the lysosomal glucocerebrosidase GBA, and ageing represent major risk factors for developing Parkinson’s disease (PD). Recently, more than fifty other lysosomal storage disorder gene variants have been identified in PD, im...

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Publicado en:Mol Neurodegener
Autores principales: Huebecker, Mylene, Moloney, Elizabeth B., van der Spoel, Aarnoud C., Priestman, David A., Isacson, Ole, Hallett, Penelope J., Platt, Frances M.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6842240/
https://ncbi.nlm.nih.gov/pubmed/31703585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-019-0339-z
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