Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age

This report demonstrates insoluble alpha-synuclein (aSYN)+ aggregates in human sporadic Parkinson’s disease (PD) midbrain that are linearly correlated with loss of glucocerebrosidase (GCase) activity. To identify early protein-lipid interactions that coincide with loss of lipid homeostasis, an aging...

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Published in:Sci Rep
Main Authors: Brekk, Oeystein R., Moskites, Alyssa, Isacson, Ole, Hallett, Penelope J.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6185981/
https://ncbi.nlm.nih.gov/pubmed/30315256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-33474-z
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