Episomal HBV persistence within transcribed host nuclear chromatin compartments involves HBx

BACKGROUND: In hepatocyte nuclei, hepatitis B virus (HBV) genomes occur episomally as covalently closed circular DNA (cccDNA). The HBV X protein (HBx) is required to initiate and maintain HBV replication. The functional nuclear localization of cccDNA and HBx remains unexplored. RESULTS: To identify...

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Bibliografiske detaljer
Udgivet i:Epigenetics Chromatin
Main Authors: Hensel, Kai O., Cantner, Franziska, Bangert, Felix, Wirth, Stefan, Postberg, Jan
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6015472/
https://ncbi.nlm.nih.gov/pubmed/29933745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-018-0204-2
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