Metabolomic Profiling in Acute ST‐Segment–Elevation Myocardial Infarction Identifies Succinate as an Early Marker of Human Ischemia–Reperfusion Injury

BACKGROUND: Ischemia–reperfusion injury following ST‐segment–elevation myocardial infarction (STEMI) is a leading determinant of clinical outcome. In experimental models of myocardial ischemia, succinate accumulation leading to mitochondrial dysfunction is a major cause of ischemia–reperfusion injur...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Kohlhauer, Matthias, Dawkins, Sam, Costa, Ana S. H., Lee, Regent, Young, Timothy, Pell, Victoria R., Choudhury, Robin P., Banning, Adrian P., Kharbanda, Rajesh K., Saeb‐Parsy, Kourosh, Murphy, Michael P., Frezza, Christian, Krieg, Thomas, Channon, Keith M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6015393/
https://ncbi.nlm.nih.gov/pubmed/29626151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.117.007546
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