Metabolomic Profiling in Acute ST‐Segment–Elevation Myocardial Infarction Identifies Succinate as an Early Marker of Human Ischemia–Reperfusion Injury

BACKGROUND: Ischemia–reperfusion injury following ST‐segment–elevation myocardial infarction (STEMI) is a leading determinant of clinical outcome. In experimental models of myocardial ischemia, succinate accumulation leading to mitochondrial dysfunction is a major cause of ischemia–reperfusion injur...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Am Heart Assoc
Egile Nagusiak: Kohlhauer, Matthias, Dawkins, Sam, Costa, Ana S. H., Lee, Regent, Young, Timothy, Pell, Victoria R., Choudhury, Robin P., Banning, Adrian P., Kharbanda, Rajesh K., Saeb‐Parsy, Kourosh, Murphy, Michael P., Frezza, Christian, Krieg, Thomas, Channon, Keith M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2018
Gaiak:
Original Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6015393/
https://ncbi.nlm.nih.gov/pubmed/29626151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.117.007546
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