Gene Transfer of Engineered Calmodulin Alleviates Ventricular Arrhythmias in a Calsequestrin‐Associated Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia

BACKGROUND: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a familial arrhythmogenic syndrome characterized by sudden death. There are several genetic forms of CPVT associated with mutations in genes encoding the cardiac ryanodine receptor (RyR2) and its auxiliary proteins including...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Liu, Bin, Walton, Shane D., Ho, Hsiang‐Ting, Belevych, Andriy E., Tikunova, Svetlana B., Bonilla, Ingrid, Shettigar, Vikram, Knollmann, Bjorn C., Priori, Silvia G., Volpe, Pompeo, Radwański, Przemysław B., Davis, Jonathan P., Györke, Sándor
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6015318/
https://ncbi.nlm.nih.gov/pubmed/29720499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.117.008155
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