The Catecholaminergic Polymorphic Ventricular Tachycardia Mutation R33Q Disrupts the N-terminal Structural Motif That Regulates Reversible Calsequestrin Polymerization

Calsequestrin undergoes dynamic polymerization with increasing calcium concentration by front-to-front dimerization and back-to-back packing, forming wire-shaped structures. A recent finding that point mutation R33Q leads to lethal catecholaminergic polymorphic ventricular tachycardia (CPVT) implies...

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Detalhes bibliográficos
Main Authors: Bal, Naresh C., Sharon, Ashoke, Gupta, Subash C., Jena, Nivedita, Shaikh, Sana, Gyorke, Sandor, Periasamy, Muthu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878038/
https://ncbi.nlm.nih.gov/pubmed/20353949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.096354
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