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First Insight on Small Molecules as Cardiac Calsequestrin Stabilizers

[Image: see text] Catecholaminergic polymorphic ventricular tachycardia (CPVT) is caused by mutations of cardiac calsequestrin (CASQ2) that impair its characteristic ability of Ca(2+)-induced polymerization–depolymerization. However, stabilizing the CASQ2 polymer by pharmacological agents to treat C...

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Bibliografiske detaljer
Udgivet i:ACS Omega
Main Authors: Chakravarty, Harapriya, Bal, Chandralata, Yadav, Monika, Jena, Nivedita, Bal, Naresh C., Sharon, Ashoke
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2019
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6682146/
https://ncbi.nlm.nih.gov/pubmed/31460256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.9b01113
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