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Concept of DNA Lesion Longevity and Chromosomal Translocations

A subset of chromosomal translocations related to B cell malignancy in human patients arise due to DNA breaks occurring within defined 20 to 600 basepair zones. Several factors influence the breakage rate at these sites including transcription, DNA sequence, and topological tension. These factors fa...

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Publicat a:Trends Biochem Sci
Autors principals: Pannunzio, Nicholas R., Lieber, Michael R.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6014902/
https://ncbi.nlm.nih.gov/pubmed/29735400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2018.04.004
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