Current CRISPR gene drive systems are likely to be highly invasive in wild populations

Recent reports have suggested that self-propagating CRISPR-based gene drive systems are unlikely to efficiently invade wild populations due to drive-resistant alleles that prevent cutting. Here we develop mathematical models based on existing empirical data to explicitly test this assumption for pop...

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Udgivet i:eLife
Main Authors: Noble, Charleston, Adlam, Ben, Church, George M, Esvelt, Kevin M, Nowak, Martin A
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2018
Fag:
Genetics and Genomics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6014726/
https://ncbi.nlm.nih.gov/pubmed/29916367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.33423
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