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The degradation pathway of a model misfolded protein is determined by aggregation propensity
Protein homeostasis in the secretory pathway is maintained by a hierarchy of quality control checkpoints, including endoplasmic reticulum–associated degradation (ERAD), which leads to the destruction of misfolded proteins in the ER, as well as post-ER proteolysis. Although most aberrant proteins are...
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| Veröffentlicht in: | Mol Biol Cell |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The American Society for Cell Biology
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6014095/ https://ncbi.nlm.nih.gov/pubmed/29688814 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E18-02-0117 |
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