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On the prevalence of bridged macrocyclic pyrroloindolines formed in regiodivergent alkylations of tryptophan

A Friedel–Crafts alkylation is described that efficiently transforms tryptophan-containing peptides into macrocycles of varying ring connectivity. Factors are surveyed that influence the distribution of regioisomers, with a focus on indole C3-alkylations leading to bridged endo-pyrroloindolines. We...

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Bibliografski detalji
Izdano u:Chem Sci
Glavni autori: Rose, Tristin E., Curtin, Brice H., Lawson, Kenneth V., Simon, Adam, Houk, K. N., Harran, Patrick G.
Format: Artigo
Jezik:Inglês
Izdano: Royal Society of Chemistry 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6014094/
https://ncbi.nlm.nih.gov/pubmed/30155060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc04612b
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