Lysyl oxidase-like 2 inhibition ameliorates glomerulosclerosis and albuminuria in diabetic nephropathy

Diabetic nephropathy is characterised by the excessive amount of extracellular matrix in glomeruli and tubulointerstitial space. Lysyl oxidase-like 2 (LOXL2) is elevated in renal fibrosis and known to play key roles in ECM stabilisation by facilitating collagen cross-links, epithelial to mesenchymal...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Stangenberg, Stefanie, Saad, Sonia, Schilter, Heidi C., Zaky, Amgad, Gill, Anthony, Pollock, Carol A., Wong, Muh Geot
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013429/
https://ncbi.nlm.nih.gov/pubmed/29930330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-27462-6
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