A Cationic-Independent Mannose 6-Phosphate Receptor Inhibitor (PXS64) Ameliorates Kidney Fibrosis by Inhibiting Activation of Transforming Growth Factor-β(1)

The activity of transforming growth factor-β1 (TGF-β(1)) is regulated by its conversion from the latent to the active form. We have previously shown that the conversion is at least in part mediated by the cationic-independent mannose 6-phosphate receptor (CI-M6PR), as the CI-M6PR inhibitor, PXS-25 h...

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Udgivet i:PLoS One
Main Authors: Zhang, Jie, Wong, Muh Geot, Wong, May, Gross, Simon, Chen, Jason, Pollock, Carol, Saad, Sonia
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319899/
https://ncbi.nlm.nih.gov/pubmed/25658916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116888
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