Orphan nuclear receptor TLX contributes to androgen insensitivity in castration-resistant prostate cancer via its repression of androgen receptor transcription

The metastatic castration-resistant prostate cancer (CRPC) is a lethal form of prostate cancer, in which the expression of androgen receptor (AR) is highly heterogeneous. Indeed, lower AR expression and attenuated AR signature activity is shown in CRPC tissues, especially in the subset of neuroendoc...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncogene
Auteurs principaux: Jia, Lin, Wu, Dinglan, Wang, Yuliang, You, Wenxing, Wang, Zhu, Xiao, Lijia, Cai, Ganhui, Xu, Zhenyu, Zou, Chang, Wang, Fei, Teoh, Jeremy Yuen-Chun, Ng, Chi-Fai, Yu, Shan, Chan, Franky L.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013422/
https://ncbi.nlm.nih.gov/pubmed/29555975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0198-z
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