Orphan nuclear receptor TLX promotes immunosuppression via its transcriptional activation of PD-L1 in glioma

BACKGROUND: High-grade gliomas are rapidly progressing tumors of the central nervous system, and are associated with poor prognosis and highly immunosuppressive microenvironments. Meanwhile, a better understanding of PD-L1, a major prognostic biomarker for checkpoint immune therapy, regulation may p...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Zhou, Jiayi, Pei, Xiaojuan, Yang, Yingui, Wang, Zhu, Gao, Weijie, Ye, Ran, Zhang, Xiantong, Liu, Jiangang, Liu, Zhuohao, Yang, Xinzhi, Tao, Jingli, Gu, Chunshan, Hu, Wei, Chan, Franky Lueng, Li, Xin, Mao, Jie, Wu, Dinglan
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2021
Assuntos:
Basic Tumor Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8055120/
https://ncbi.nlm.nih.gov/pubmed/33858847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001937
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