Orphan nuclear receptor TLX contributes to androgen insensitivity in castration-resistant prostate cancer via its repression of androgen receptor transcription

The metastatic castration-resistant prostate cancer (CRPC) is a lethal form of prostate cancer, in which the expression of androgen receptor (AR) is highly heterogeneous. Indeed, lower AR expression and attenuated AR signature activity is shown in CRPC tissues, especially in the subset of neuroendoc...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Jia, Lin, Wu, Dinglan, Wang, Yuliang, You, Wenxing, Wang, Zhu, Xiao, Lijia, Cai, Ganhui, Xu, Zhenyu, Zou, Chang, Wang, Fei, Teoh, Jeremy Yuen-Chun, Ng, Chi-Fai, Yu, Shan, Chan, Franky L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013422/
https://ncbi.nlm.nih.gov/pubmed/29555975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0198-z
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