Nuclear receptor ERRα contributes to castration-resistant growth of prostate cancer via its regulation of intratumoral androgen biosynthesis

Enhanced intratumoral androgen biosynthesis and persistent androgen receptor (AR) signaling are key factors responsible for the relapse growth of castration-resistant prostate cancer (CRPC). Residual intraprostatic androgens can be produced by de novo synthesis of androgens from cholesterol or conve...

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Vydáno v:Theranostics
Hlavní autoři: Xu, Zhenyu, Ma, Taiyang, Zhou, Jianfu, Gao, Weijie, Li, Youjia, Yu, Shan, Wang, Yuliang, Chan, Franky Leung
Médium: Artigo
Jazyk:Inglês
Vydáno: Ivyspring International Publisher 2020
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7086365/
https://ncbi.nlm.nih.gov/pubmed/32226548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.35589
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