Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation

Nuclear factor κB (NF-κB) is a transcription factor important for regulating innate and adaptive immunity, cellular proliferation, apoptosis, and senescence. Dysregulation of NF-κB and its upstream regulator IκB kinase (IKK) contributes to the pathogenesis of multiple inflammatory and degenerative d...

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Bibliografski detalji
Izdano u:PLoS Biol
Glavni autori: Zhao, Jing, Zhang, Lei, Mu, Xiaodong, Doebelin, Christelle, Nguyen, William, Wallace, Callen, Reay, Daniel P., McGowan, Sara J., Corbo, Lana, Clemens, Paula R., Wilson, Gabriela Mustata, Watkins, Simon C., Solt, Laura A., Cameron, Michael D., Huard, Johnny, Niedernhofer, Laura J., Kamenecka, Theodore M., Robbins, Paul D.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2018
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013238/
https://ncbi.nlm.nih.gov/pubmed/29889904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2004663
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