Flap endonuclease 1 is involved in cccDNA formation in the hepatitis B virus

Hepatitis B virus (HBV) is one of the major etiological pathogens for liver cirrhosis and hepatocellular carcinoma. Chronic HBV infection is a key factor in these severe liver diseases. During infection, HBV forms a nuclear viral episome in the form of covalently closed circular DNA (cccDNA). Curren...

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Udgivet i:PLoS Pathog
Main Authors: Kitamura, Kouichi, Que, Lusheng, Shimadu, Miyuki, Koura, Miki, Ishihara, Yuuki, Wakae, Kousho, Nakamura, Takashi, Watashi, Koichi, Wakita, Takaji, Muramatsu, Masamichi
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013022/
https://ncbi.nlm.nih.gov/pubmed/29928064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007124
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