CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system—New mode of action for caffeine

We show that the cyclin-dependent kinase inhibitor 1B (CDKN1B)/p27, previously known as a cell cycle inhibitor, is also localized within mitochondria. The migratory capacity of endothelial cells, which need intact mitochondria, is completely dependent on mitochondrial p27. Mitochondrial p27 improves...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Ale-Agha, Niloofar, Goy, Christine, Jakobs, Philipp, Spyridopoulos, Ioakim, Gonnissen, Stefanie, Dyballa-Rukes, Nadine, Aufenvenne, Karin, von Ameln, Florian, Zurek, Mark, Spannbrucker, Tim, Eckermann, Olaf, Jakob, Sascha, Gorressen, Simone, Abrams, Marcel, Grandoch, Maria, Fischer, Jens W., Köhrer, Karl, Deenen, René, Unfried, Klaus, Altschmied, Joachim, Haendeler, Judith
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013014/
https://ncbi.nlm.nih.gov/pubmed/29927970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2004408
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