The Anti-Apoptotic Properties of APEX1 in the Endothelium Require the First 20 Amino Acids and Converge on Thioredoxin-1

The APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1) has a disordered N-terminus, a redox, and a DNA repair domain. APEX1 has anti-apoptotic properties, which have been linked to both domains depending on cell type and experimental conditions. Aims: As protection against apoptosis is a ha...

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Détails bibliographiques
Publié dans:Antioxid Redox Signal
Auteurs principaux: Dyballa-Rukes, Nadine, Jakobs, Philipp, Eckers, Anna, Ale-Agha, Niloofar, Serbulea, Vlad, Aufenvenne, Karin, Zschauer, Tim-Christian, Rabanter, Lothar L., Jakob, Sascha, von Ameln, Florian, Eckermann, Olaf, Leitinger, Norbert, Goy, Christine, Altschmied, Joachim, Haendeler, Judith
Format: Artigo
Langue:Inglês
Publié: Mary Ann Liebert, Inc. 2017
Sujets:
Forum Original Research Communication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5397250/
https://ncbi.nlm.nih.gov/pubmed/27835927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2016.6799
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