CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system—New mode of action for caffeine

We show that the cyclin-dependent kinase inhibitor 1B (CDKN1B)/p27, previously known as a cell cycle inhibitor, is also localized within mitochondria. The migratory capacity of endothelial cells, which need intact mitochondria, is completely dependent on mitochondrial p27. Mitochondrial p27 improves...

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書誌詳細
出版年:PLoS Biol
主要な著者: Ale-Agha, Niloofar, Goy, Christine, Jakobs, Philipp, Spyridopoulos, Ioakim, Gonnissen, Stefanie, Dyballa-Rukes, Nadine, Aufenvenne, Karin, von Ameln, Florian, Zurek, Mark, Spannbrucker, Tim, Eckermann, Olaf, Jakob, Sascha, Gorressen, Simone, Abrams, Marcel, Grandoch, Maria, Fischer, Jens W., Köhrer, Karl, Deenen, René, Unfried, Klaus, Altschmied, Joachim, Haendeler, Judith
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2018
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013014/
https://ncbi.nlm.nih.gov/pubmed/29927970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2004408
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