CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system—New mode of action for caffeine

We show that the cyclin-dependent kinase inhibitor 1B (CDKN1B)/p27, previously known as a cell cycle inhibitor, is also localized within mitochondria. The migratory capacity of endothelial cells, which need intact mitochondria, is completely dependent on mitochondrial p27. Mitochondrial p27 improves...

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Veröffentlicht in:PLoS Biol
Hauptverfasser: Ale-Agha, Niloofar, Goy, Christine, Jakobs, Philipp, Spyridopoulos, Ioakim, Gonnissen, Stefanie, Dyballa-Rukes, Nadine, Aufenvenne, Karin, von Ameln, Florian, Zurek, Mark, Spannbrucker, Tim, Eckermann, Olaf, Jakob, Sascha, Gorressen, Simone, Abrams, Marcel, Grandoch, Maria, Fischer, Jens W., Köhrer, Karl, Deenen, René, Unfried, Klaus, Altschmied, Joachim, Haendeler, Judith
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013014/
https://ncbi.nlm.nih.gov/pubmed/29927970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2004408
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