CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system—New mode of action for caffeine

We show that the cyclin-dependent kinase inhibitor 1B (CDKN1B)/p27, previously known as a cell cycle inhibitor, is also localized within mitochondria. The migratory capacity of endothelial cells, which need intact mitochondria, is completely dependent on mitochondrial p27. Mitochondrial p27 improves...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:PLoS Biol
Main Authors: Ale-Agha, Niloofar, Goy, Christine, Jakobs, Philipp, Spyridopoulos, Ioakim, Gonnissen, Stefanie, Dyballa-Rukes, Nadine, Aufenvenne, Karin, von Ameln, Florian, Zurek, Mark, Spannbrucker, Tim, Eckermann, Olaf, Jakob, Sascha, Gorressen, Simone, Abrams, Marcel, Grandoch, Maria, Fischer, Jens W., Köhrer, Karl, Deenen, René, Unfried, Klaus, Altschmied, Joachim, Haendeler, Judith
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2018
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013014/
https://ncbi.nlm.nih.gov/pubmed/29927970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2004408
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares